4-[4-[(1,2-二氢-2-氧代-3H-吲哚-3-基亚基)甲基]苯基]-1-哌嗪甲醛
SU4984(SU4984)
CAS: 186610-89-9
化学式: C20H19N3O2
| 中文名 | SU4984 |
| 英文名 | SU4984 |
| 别名 | 化合物SU4984 4-[4-[(1,2-二氢-2-氧代-3H-吲哚-3-基亚基)甲基]苯基]-1-哌嗪甲醛 |
| 英文别名 | SU4984 CIVENTICHEM CV-409 |
| CAS | 186610-89-9 |
| 化学式 | C20H19N3O2 |
| 分子量 | 333.38 |
| 溶解度 | 溶于DMSO |
| 存储条件 | -20℃ |
| 外观 | 橙色至红色结晶固体。 |
| 产品用途 | SU4984 is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM). |
| 参考资料 展开查看 | 1: Matsuo M, Yamada S, Koizumi K, Sakurai H, Saiki I. Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells. Eur J Cancer. 2007 Jul;43(11):1748-54. Epub 2007 Jun 13. PubMed PMID: 17570654. 2: Mologni L, Sala E, Cazzaniga S, Rostagno R, Kuoni T, Puttini M, Bain J, Cleris L, Redaelli S, Riva B, Formelli F, Scapozza L, Gambacorti-Passerini C. Inhibition of RET tyrosine kinase by SU5416. J Mol Endocrinol. 2006 Oct;37(2):199-212. PubMed PMID: 17032739. 3: Welsh M, Welsh C, Ekman M, Dixelius J, Hägerkvist R, Annerén C, Akerblom B, Mahboobi S, Chandrasekharan S, Liu ET. The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. Biochem J. 2004 Aug 15;382(Pt 1):261-8. PubMed PMID: 15186217; PubMed Central PMCID: PMC1133939. 4: Fuhrmann G, Leisser C, Rosenberger G, Grusch M, Huettenbrenner S, Halama T, Mosberger I, Sasgary S, Cerni C, Krupitza G. Cdc25A phosphatase suppresses apoptosis induced by serum deprivation. Oncogene. 2001 Jul 27;20(33):4542-53. PubMed PMID: 11494150. |
4-[4-[(1,2-二氢-2-氧代-3H-吲哚-3-基亚基)甲基]苯基]-1-哌嗪甲醛 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3 ml | 14.998 ml | 29.996 ml |
| 5 mM | 0.6 ml | 3 ml | 5.999 ml |
| 10 mM | 0.3 ml | 1.5 ml | 3 ml |
| 5 mM | 0.06 ml | 0.3 ml | 0.6 ml |
最后更新：2024-01-02 23:10:35
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